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Objectives:
This study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease (NAFLD). Methods: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3 Â 10 9 colony forming units [CFU]; Bifidobacterium lactis DSMZ 32269, 6 Â 10 9 CFU; Bifidobacterium bifidum ATCC SD6576, 2 Â 10 9 CFU; Lactobacillus rhamnosus DSMZ 21690, 2 Â 10 9 CFU) or placebo for 12 weeks.
Results:
After intervention, in the probiotic group the mean levels of alanine aminotransferase decreased from 32.8 (19.6) to 23.1 (9.9) U/L (P ¼ 0.02) and mean aspartate aminotransferase decreased from 32.2 (15.7) to 24.3 (7.7) U/L (P ¼ 0.02). Likew…