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High risk NBL is defined based on the patient's age (> 18 months), disease metastasis, tumor histology, and MYCN gene amplification.
Abbas & Samkari 2022 Current Cancer Therapy Reviews 18: 14-40
High risk NBL is diagnosed in nearly 40% of patients, mainly those > 18 months of age, and is associated with aggressive clinical behavior.
Abbas & Samkari 2022 Current Cancer Therapy Reviews 18: 14-40
High risk NBL carries a high mortality rate accounting for nearly 15% of pediatric cancer deaths.
Abbas & Samkari 2022 Current Cancer Therapy Reviews 18: 14-40
However, most mortalities are attributed to the high frequency of disease relapse (50%) and disease reactiveness to therapy (20%).
Abbas & Samkari 2022 Current Cancer Therapy Reviews 18: 14-40…