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DNA alkylating agents are used in treating leiomyosarcoma, especially in advanced cases or when other treatments have been tried. However, they are not the main first-choice treatment for all leiomyosarcoma situations. The most important alkylating agents for leiomyosarcoma are dacarbazine, temozolomide, ifosfamide (in certain treatment plans), and trabectedin. Uterine leiomyosarcoma is of special interest because some tumors have defects in homologous rec…