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Probiotics have a modest yet significant impact on alleviating symptoms in individuals with irritable bowel syndrome (IBS), as indicated by meta-analyses (1).
It is a randomized, double-blind, placebo-controlled intervention trial studying Lacticaseibacillus casei Shirota or placebo in 80 enrolled patients with irritable bowel syndrome (IBS) (Rome II) (1).
Decrease of at least 30% in a composite mean symptom score (MSS) at week 8 on the basis of an intention-to-treat analysis (1).
During the intervention period, the mean relative improvement in the main symptom score (MSS) or any individual symptom score did…