Adverse events / Safety & Carrageenan (CGN)

In the 1970s, the safety of carrageenan (CGN) types was brought into question. During this time, studies utilized CGN to induce inflammation in animal models. It specifically induces edema in hind paw of the rat as an assay for antiinflammatory drugs (Winter et al. 1962 Exp Biol Med 111(3): 544-547). In rodents, CGN exposure led to ulcerative lesions that were similar to human ulcerative colitis (Watt & Marcus 1973 Gut 14(6): 506-510). However, it is important to note that the CGN used in these studies was a degraded form known as poligeenan.

see also:
[Carrageenan (CGN) & Inflammatory Bowel Dise…