Medical Research Finder

Start
Features
Free trial / FAQ

Researchers
Physicians
Pharmacists
Ecotrophologists
Product Managers
in Health Industries

Loading…

© 2026 meRfi®

Medical Research Finder

Legal Notice
Privacy
Terms of Use

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

meRfi® AI Chat

Interleukin-22 (IL-22) & Signal transducer and activator of transcription 3 (STAT3)

Welcome to meRfi Microbiome!

Please register to continue your trial period!

meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

Register for a free trial

Navigation

Contents

IL-22 comes from Th1, Th17, ILC3 cells (2, 3). Target cells for released Interleukin-22 (IL-22) are Enterocytes / Intestinal Epithelial Cells (IECs) (1). IL-22 provides protection through the STAT3 signal transduction pathway.

IL-22 induces production of antimicrobial peptides (2, 3, 4, 5, 6, 7):

BD-2

BD-3

Calcium-Binding Protein A7 (S100A7)

[Calcium-Binding Protein A8 (S100A8)](bra…

References (Sources)

Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut
Mahapatro et al. 2021
Review
Cytokine-mediated regulation of antimicrobial proteins
Kolls et al. 2009 Nat Rev Immunol 8: 829-835
Review
IL-22 Increases the Innate Immunity of Tissues
Wolk et al. 2004 Immunity 21: 241-254
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular diﬀerentiation, and mobility in keratinocytes: A potential role in psoriasis
Wolk et al. 2006 Eur. J. Immunol. 36: 1309-1323
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang et al. 2006 J. Exp. Med. 203: 2271-2279
Interleukin-22 mediates early host defense against attaching and eﬀacing bacterial pathogens
Zheng et al. 2008 Nat. Med. 14: 282-289
Lactobacillus Accelerates ISCs Regeneration to Protect the Integrity of Intestinal Mucosa through Activation of STAT3 Signaling Pathway Induced by LPLs Secretion of IL-22.
Hou et al. 2018 Cell Death Differ. 25: 1657–1670

AI Chat

7/1/2026

Chat with our artificial intelligence: