Inflammatory Bowel Disease (IBD) & Interleukin-10 (IL-10)

Some cytokines that play a prominent role in the pathogenesis of patients with Inflammatory Bowel Disease (IBD), such as interleukin-10 and IL-17, do not have effective targeting agents
Marafini et al. 2019 Expert Opin Biol Ther 19: 1207-17
Moschen et al. 2019 Nat Rev Gastroenterol Hepatol 16: 185-96

IL‑10 signalling is essential for regulating intestinal mucosal inflammation. Loss of either IL‑10 or its receptor, IL‑10R, leads to severe inflammatory bowel disease in both mice and humans.
Zhu et al. 2017 Gastroenterology Res 10: 65-69
Glocker et al. 2011 Ann NY Acad Sci 1246: 102-107
Li et …