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These are a subset of Nrf2 activators that specifically bind to and activate Nuclear factor erythroid 2-related factor 2 (NFE2L2) directly, leading to its activation and subsequent transcription of target genes. Agonists typically have a direct and specific action on the Nrf2 protein itself.
One NRF2 activator has received clinical approval and several electrophilic modifiers of the cysteine-based sensor KEAP1 and inhibitors of its interaction with NRF2 are now in clinical development
[Alkyl catechol…