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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Gut microbiota & Sorivudine

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Gut microbiota produces (E)-5-(2-bromovinyl)uracil, which inactivates a key liver enzyme, leading to lethal toxicity of 5-fluorouracil when coadministered with 5-fluorouracil by hydrolysis.
Li & Jia 2013 Clin. Pharmacol. Ther. 94: 574–581

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Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity
Li & Jia 2013 Clin. Pharmacol. Ther. 94: 574–581
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5(E)(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil
Nakayama et al. 1997 Pharmacogenetics 7: 35-43

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Gut microbiota & Sorivudine

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