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When cells become cancerous, the morphology, cellular location and metabolic mode of the mitochondria change accordingly.
These mitochondrial changes can have two opposing effects on cancer: procancer and anticancer effects.
Specifically, mitochondria play roles in the fight against cancer by participating in processes such as ferroptosis, mitophagy and antitumor immunity.
Contrastingly, cancer cells can also enslave mitochondria to give them the conditions necessary for growth and metastasis.
Moreover, through mitochondria, cancer cells can escape from immune surveillance, resulting in their immune escape and enhanced …