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The Farnesoid X receptor (FXR / NR1H4) has also been investigated as a therapeutic target for Cardiometabolic Disease (CMD)
Farnesoid X receptor (FXR / NR1H4) serves a much broader role in hepatic metabolism by controlling aspects of carbohydrate, lipid, and amino acid metabolism
In enterocytes, FXR induces I-BABP, OST α and OST β and inhibits ASBT (58-60), leading to reduced uptake and increased secretion
Grober et al. 1999 J Biol Chem 274: 29749-54
Neimark et al. 2004 Hepatology 40: 149-56
Lee et al. 2006a J Lipid Res 47: 201-14…