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NLRX1 (NOD-like receptor X1) as anti-inflammatory regulator is a unique member of the NLR (nucleotide-binding domain, leucine-rich repeat containing) family, localized to the mitochondria and acts as an important immunometabolic regulator, modulating inflammation, innate immunity, metabolism, and mitochondrial dynamics across various cell types and diseases.
NLRX1 is known to play a role in downregulating type-I interferon, reducing pro-inflammatory NFKB signaling, enhancing the production of reactive oxygen species, and influencing pr…