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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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ATP-Binding Cassette Transporter 1 (ABCA1)

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Contents

ATP-binding cassette transporter A1 (ABCA1) is a membrane transporter that effluxes cholesterol from cells, particularly Astroglia / Astrocytes, into the extracellular space (1)

ATP-binding cassette transporter 1 (ABCA1) (2) is dedicated to maintaining cellular cholesterol homeostasis and preventing foam cell formation by facilitating the removal of cellular lipids (3, 4).

ABCA1 has been identified as having anti-inflammatory properties (5).

References:

(1) Paseban et al. 2023 Expert Opinion on Therapeutic Targets 27(7): 531-552
(2) Chawla et al. 2001 Mol Cell 7: 161-171
(3) Cavelier et al. 2006 Biochim Biophys Acta 1761: 655-666
(4) Out et al. 2008 Arter Thromb Vasc Biol 28: 258-264
(5) Yin et al. 2010 …

References (Sources)

A PPAR-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
Chawla et al. 2001 Mol Cell 7: 161-171
ATP-Binding Membrane Cassette Transporter A1 (ABCA1): A Possible Link between Inflammation and Reverse Cholesterol Transport
Yin et al. 2010 Mol Med 16: 438-449
Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels
Out et al. 2008 Arter Thromb Vasc Biol 28: 258-264
Lipid Efflux by the ATP-Binding Cassette Transporters ABCA1 and ABCG1
Cavelier et al. 2006 Biochim Biophys Acta 1761: 655-666
Review
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review
Paseban et al. 2023 Expert Opinion on Therapeutic Targets 27(7): 531-552
Review
Vitamin D counteracts lipid accumulation, augments free fatty acid-induced ABCA1 and CPT-1A expression while reducing CD36 and C/EBP β protein levels in monocyte-derived macrophages
Marino et al. 2022 Biomedicines 10: 775

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