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MMG-11 is a small-molecule antagonist that selectively inhibits TLR2/1 signaling. It contains a pyrogallol (1,2,3-triphenol) motif, which renders it highly susceptible to oxidation, limiting its usability in routine or extended experiments under aerobic conditions. MMG-11 does not directly interact with TLR1 or TLR6 subunits of the TLR complex, showing specificity for TLR2-mediated signaling pathways.
see also:
Toll-like receptor 1 (TLR-1) / Toll-like receptor 2 (TLR-2) heterodimer (TLR-1/TLR-2) / MYD88 / NFKB signaling pathway
[Toll-like receptor 2 (TLR-2) / Toll-like receptor 6 (TLR-6) heterodimer (TLR-2/TLR-6…