CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

Recent studies have also reported that resident memory CD8 +T cells (TRM) cells can increase circulating effector and memory T cells. Still, they remain predisposed to migrate back to their tissue of origin (2). Nevertheless, these cells are among the first cells able to act in healthy or tumor tissues, and because of their local mobility, they play a major role in tissue immune surveillance (3,4). In addition, these TRM cells appear to be more cytotoxic than other CD8 + T effector cells, as CD103 expression is correlated with the levels of granzymes (6) ([Karaki et al.…