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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Alzheimer's disease (AD) & Soluble triggering receptor expressed on myeloid cells 2 (sTREM2)

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Soluble triggering receptor expressed on myeloid cells 2 (sTREM2), found in cerebrospinal fluid, has been linked to Alzheimer's disease. TREM2 is crucial for the activation, survival, and phagocytosis of microglia. Despite this, the exact pathophysiological role that sTREM2 plays in Alzheimer's disease remains unclear.
Deming et al. 2019 Sci Transl Med 11: eaau2291

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Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
Shi & Holtzman 2018 Nat Rev Immunol 18(12): 759-772
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Deming et al. 2019 Sci Transl Med 11: eaau2291

7/2/2026