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SEA-CD40 is an investigational, non-fucosylated, humanized monoclonal IgG1 antibody that activates CD40, an immune-activating tumor necrosis factor receptor superfamily member.
It exhibits enhanced binding to activating FcγRIIIa, possibly enabling greater immune stimulation than other CD40 (Tumor necrosis factor receptor superfamily member 5) agonists
Coveler et al. 2023 J Immunother Cancer 11(6): e005584…