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Soluble B7-H3 is elevated in patients with sepsis when compared with healthy persons and is even higher in patients who died from sepsis
Whether soluble B7H3 represents a predictive or prognostic factor for sepsis is unclear as this was a small study and other confounding factors could have influenced the reported results
B7-H3 substantially augmented pro-inflammatory cytokine production in the development of pneumococcal meningitis in a murine model
Chen et al. 2012 J Immunol. 189(1): 347–355
B7-H3 is upregulated in the colon…