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In conclusion, the early 1990s marked a pivotal discovery in diabetes management, as bile acid sequestrants were found to enhance glycaemic control in individuals with type 2 diabetes. This observation was later substantiated by numerous studies. Notably, the activation of TGR5 on enteroendocrine L cells has been proposed to influence the secretion of incretin hormones, with a particular emphasis on glucagon-like peptide 1 (GLP1).
Animal a…