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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Colorectal Cancer (CRC) & Enterotoxigenic Bacteroides fragilis (ETBF)

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Contents

Enterotoxigenic Bacteroides fragilis (ETBF) has been proposed as protumoral pathobiont based on experimental data of animal models
Yu 2018

More than 50% of Familial adenomatous polyposis (FAP) patients harbor colonic biofilm with Enterotoxigenic Bacteroides fragilis (ETBF)
Dejea et al. 2018 Science 359: 592-597

Enterotoxigenic Bacteroides fragilis (ETBF) is increased in precancerous Colorectal Cancer (CRC) lesions such as familial adenomatous polyposis (FAP) and promotes colonic tumorigenesis by increasing interleukin-17 (IL-17)-depen…

References (Sources)

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
Wu et al. 2009 Nat. Med. 15: 1016
Bacteroides fragilis toxin coordinates a pro-carcinogenic inﬂammatory cascade via targeting of colonic epithelial cells
Chung et al. 2018a Cell Host Microbe 23: 203-214
Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer
Gagnaire et al. 2017 Nat. Rev. Microbiol. 15: 109-128
Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes
Sears 2009 Clin. Microbiol. Rev. 22: 349–369
Review
Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis
Yu 2018
Review
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Dejea et al. 2018 Science 359: 592-597
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis induced colon tumorigenesis
Goodwin et al. 2011

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7/1/2026

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