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Soft Tissue Sarcoma (STS) are a diverse group of rare tumors. They are primarily treated with surgery. For high-risk STS in the extremities, preoperative radiotherapy is often recommended. Neoadjuvant chemotherapy, usually involving doxorubicin with ifosfamide, has proven effective for STS in the limbs and trunk wall. In the metastatic setting, second-line chemotherapy is typically guided by histology. Molecular targeted agents are employed across different histologies. Although the use of immunotherapy in STS is still in its early…