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RNA interference (RNAi) has generated considerable excitement for its potential cancer therapeutic applications.
Because of the difficulties in delivering a large amount of Small interfering RNAs (siRNAs) to cancer cells and the short half-life of siRNA, it is important to choose an efficient delivery system for transduction of siRNA into target cells.
Oncolytic adenovirus offers a better platform by virtue of its high transfection efficiency and selective replication in cancer cells.
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