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All mucosal surfaces are flooded with IgA, produced at concentrations exceeding those of all other Ig isotypes combined.
The barrier protection function of IgA is well described; recent work suggests that IgA also plays a crucial role in shaping the composition and function of the commensal microbiota
The high IgA-inducing B. ovatus strains preferentially elicited more Secreted Immunoglobulin A (sIgA) / IgA production in the large intestine through the T cell-dependent B …