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Extracellular ATP is released from live cells in controlled conditions, as well as dying cells in inflammatory conditions, and, thereby, regulates T cell responses, including Th17 cell induction. Additionally, ATP is secreted by a subset of intestinal bacteria.
Tumor cells treated with chemotherapy - effective adjuvans primes antitumor T cell responses through released ATP
ATP is an agonist at P2X receptors and P2Y receptors
Nuttle & Dubyak 1994 J. Biol. Chem. 269…
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