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Drugs modulating microglia dysfunction and combination treatment regimens offer some promise.
It is our opinion that previous failures of anti-AD drugs suggest that soluble Amyloid-beta (Aß, Abeta) / Amyloid Plaques and tau are not appropriate Drug targets. In addition, pivotal clinical trials of future clinical candidates should avoid major protocol amendments and futility analyses. Study protocols should adopt better measures to protect study blinding and minim…