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More than 70 mutations in the PINK1 gene have been identified that can cause Parkinson's disease, with many of these mutations altering or eliminating the kinase domain, leading to a loss of protein function
Mutations in the pink1 gene have been associated with early-onset Morbus Parkinson / Parkinson's Disease (PD). Loss of PINK-1 function can lead to mitochondrial dysfunction, increased vulnerability to oxidative stress, and defects in protein sorting
see also:
[PTEN-induced kinase 1 (PINK1) (MUT)](brain://DiGa1Z…