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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Sequestosome 1

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Sequestosome 1, also known as p62, is a multifunctional protein that plays a critical role in various cellular pathways, particularly those involved in autophagy, oxidative stress response, and the ubiquitin-proteasome system.

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References (Sources)

Neuroprotective effects of p62(SQSTM1) engineered lactic acid bacteria in Alzheimer’s disease: a preclinical study
Cecarini et al. 2020 Aging (albany NY) 12:15995-16020
Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6
Into et al. 2010 J Biol Chem 285(46): 35759-69
Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma
Denk et al. 2019 Expert Opin.Ther.Targ. 23: 393-406
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