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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Protein-tyrosine phosphatase 1B (PTP1B) / PTPN1 inhibitors

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Several classes ofProtein-tyrosine phosphatase 1B (PTP1B) / PTPN1 inhibitors have been developed, targeting either the catalytic or allosteric sites, with structure-based approaches improving selectivity for PTP1B over related phosphatases
Xu et al. 2019 Cell Death Dis 10(12): 874
Liu et al. 2022 Int J Mol Sci 23(13): 7027
Sun et al. 2024 Front Cardiovasc Med 11: 1445739

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References (Sources)

Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives
Liu et al. 2022 Int J Mol Sci 23(13): 7027
Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway
Xu et al. 2019 Cell Death Dis 10(12): 874
Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics
Sun et al. 2024 Front Cardiovasc Med 11: 1445739
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Protein-tyrosine phosphatase 1B (PTP1B) / PTPN1 inhibitors

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