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Emerging evidence demonstrates that cancer-derived exosomes are enriched in immunosuppressive proteins (e.g., PD-L1)
Immune Suppression Has Been Hypothesized to Be Mediated by Exosomes from Cancer cells
A human in vitro model system shows that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells.
After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell-dependent antitumor effects on syngeneic and allogeneic established mouse tumors.
Wolfers et al., 2001 Nat Me…