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Recent preclinical and clinical studies suggest that microbiota-derived immunomodulatory metabolites (IMMs) such as short-chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs), bile acids (BAs), and indoles have the potential to enhance anti-tumor immune responses. These metabolites also play a role in modulating regulatory T (Treg) cells (; ) and are important for maintaining [intestinal homeostasis](br…