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In the realm of Butyrate / Butyric acid & Major depressive disorder / Major Depression / Depressive episode (MDD), a total of thirty-two animal studies have indicated that butyrate typically influences depressive and anxiety-like behaviors in rodents. This effect is possibly achieved through mechanisms that are anti-inflammatory, neuroplastic, epigenetic, and mediated by the gut. The preclinical findings suggest that butyrate holds therapeutic potential as a new treatment for depression, indicating the need for further clinical research.
In two randomized controlled trials, one study observed no measurable effect of a 1-week oral butyrate regimen in hea…