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Alfa-defensins are active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses but they are typically selectively active against non-commensals
Alpha-defensins are constitutively expressed in Paneth cells(brain:// (Putsep et al., 2005; Vaishnava et al., 2008) and stored in secretory large granules at the base of the crypts of the small intestine, without recognizing [MAMPs](brain://54ZISnHHMkK8rvPp…