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Butyrate / Butyric acid effect on Chemokine (C-X-C motif) ligand 8 (CXCL8) / Interleukin-8 (IL-8) is not uniform and is highly dependent on:
This highlights why results might diverge based on study design and biological model. In human gut epithelial cells, for instance, butyrate seems to have little effect, while in certain bovine cell models and in neonatal in vitro settings, it can either upregulate or downregulate CXCL8/IL-8, respectively.
Blanchet et al. 2025 Food Funct 16: 56…