Mercaptopurine & Ulcerative Colitis (UC)

• Mercaptopurine (6-MP) is not FDA or EMA approved for ulcerative colitis (UC) treatment.


• It is commonly used off-label as an immunomodulator for maintaining remission in UC.


• Its use is based on clinical guidelines and consensus recommendations.

Marafini et al. 2024 United European Gastroenterol J 12(5): 539-540
Hasskamp et al. 2025 Cochrane Database Syst Rev 2(2): CD000478

see also:
Mercaptopurine