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Human gammaherpesvirus 8 (HHV-8) is one virus that has been implicated in the development of several types of cancer. HHV-8 is known for its role in the etiology of Kaposi's sarcoma. It is also associated with lymphoproliferative diseases: primary effusion lymphoma (PEL) and a subset of multicentric Castleman disease (MCD).
The latency-associated nuclear antigen (LANA) of HHV-8 can inactivate tumor suppressor genes such as p53 and Rb, while the viral G protein-coupled receptor (vGPCR) can induce angiogenesis and inflammatory cytokine production, thereby promoting tumor grow…