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Treatment resistance to ICIs remains a significant challenge and defines the biggest unmet medical need in oncology worldwide.
Definitions of immune resistance are heterogeneous according to different clinical and biological features.
Passaro et al. 2022 J Clin Oncol 40: 598-610
There are primary and acquired resistance, related to tumor-intrinsic and tumor-extrinsic mechanisms
Passaro et al. 2022 J Clin Oncol 40: 598-610
The clinical resistance patterns determine differential clinical approaches.
Passaro et al. 2022 J Clin Oncol 40: 598-610
We highlight eight biological processes and refer to them as immune resistance nodes.
The integration of multi-omic high-dimensional analyses from patient-leve…