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Cryptosporidium tyzzeri was unexpectedly discovered when mice lacking conventional type 1 dendritic cells (cDC1) developed cryptosporidiosis. In wild-type mice, Cryptosporidium tyzzeri was passed down without causing negative health effects. However, Cryptosporidium tyzzeri induced significant changes in the intestinal immune system, including the induction of an IFN-gamma-producing Th1 response. Through TCR sequencing and both in vitro and in vivo analysis of common Th1 TCRs, it was found that Cryptosporidium tyzzeri triggered a dominant antigen-specific Th1 response. On t…