Fecal Metabolomic Signatures in CRC Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis

Fecal metabolomic signatures are associated with gut microbiome and colorectal cancer pathogenesis: (1) The levels of polyunsaturated fatty acids and sphingolipids are further increased in patients with CRC, which may represent early changes in CRC. (2) Regardless of disease status, age, or gender, there is a strong overall correlation between microbiome and metabolomics data, and the correlation is higher in women than in men. (3) The abundance of multiple bacteria in Firmicutes, Actinobacteria, and Bacteroides is strongly correlated with elevated metabolite pathways in patients.…