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According to the study identified as NCT04048174, the application of live bacteria to the diseased sinus epithelium has led to insights into gene expression profiling. This profiling highlights the role of different elements within the inflammation-microbiome-epithelial barrier axis in the context of chronic rhinosinusitis (CRS). The observed effects appear to include both the restoration of the epithelium and the modulation of innate and adaptive immune responses. These findings suggest that focusing on the sinus epithelium and microbiome could be promising avenues for developing therapies for CRS.
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