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Chronic graft-versus-host disease (cGVHD) is a significant long-term complication that can occur after allogeneic hematopoietic cell transplantation (alloHCT). This procedure is often performed to treat various malignant and non-malignant hematologic diseases. Chronic graft-versus-host disease (cGVHD) arises when the donated immune cells (the graft) recognize the recipient's body (the host) as foreign and mount an immune response against it. This immune reaction leads to inflammation and damage in various tissues and organs.
The pathophysiology of cGVHD involves several phases:
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