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For those diagnosed with locally advanced disease, single-agent cisplatin-based chemotherapy concurrent with radiation remains the mainstay of treatment.
The physical sequelae of locally advanced cervical cancer treatments stem largely from irradiation of the pelvis.
Combination chemotherapy and the incorporation of bevacizumab have shown benefits, and recent data indicate advantages with the addition of upfront immunotherapy in women whose cancer expresses programmed death ligand-1.
With the implementation of modern conformal radiotherapy techniques, the local control rate has been optimized. Nevertheless, 40% o…