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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Probiotics (living agents) & Crohn’s disease (CD)

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Contents

Currently, there are no definitive conclusions regarding the effectiveness of Probiotics (living agents) in Crohn’s disease (CD) (1, 2, 3).

Systematic reviews and meta-analyses

Review 1
According to a meta-analysis of 16 randomized, clinical trials involving 1112 participants (CRD42024611369), participants treated with probiotics showed no significant effect on relapse or endoscopic recurrence in remission, the primary objectives of this analysis. The research was conducted up to October 2024 (4).

Review 2
According to a meta-analysis of 13 randomized, clinical trials involving 896 participants, participants treated with probiotics **showed no significant benefit for induction …

References (Sources)

A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn’s disease
Bousvaros et al. 2005 Inflamm Bowel Dis. 11(9): 833–839
Efficacy and safety probiotics as adjuvant treatment for Crohn's disease: a meta-analysis of randomized controlled trials
Zheng et al. 2025 Curr Res Food Sci 10: 101061
Meta-Analysis
Lactobacillus GG in inducing and maintaining remission of Crohn’s disease
Schultz et al. 2004 BMC Gastroenterol. 4: 5
Multicenter randomized controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn’s disease after ileo-caecal resection
Van Gossum et al. 2007 Inflamm Bowel Dis. 13(2): 135–142
Probiotics for induction of remission in Crohn's disease
Limketkai et al. 2020 Cochrane Database Syst Rev 7: CD006634
Review
The Role of Probiotics in Inducing and Maintaining Remission in Crohn's Disease and Ulcerative Colitis: A Systematic Review of the Literature
Vakadaris et al. 2023 Biomedicines 11(2): 494
Review
Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn’s disease with special respect to chronic diarrhea – a pilot study
Plein & Hotz 1993 Z Gastroenterol. 31(2): 129–134

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7/1/2026

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