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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Takeda G-protein-coupled Receptor 5 (TGR5, BG37, GBPAR1) & Key Features

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Suppression of pro-inflammatory function of macrophages (Wang et al. 2011c Hepatology 54: 1421-1432; McMahan et al. 2013 J. Biol. Chem. 288: 11761-11770) ; suppression of TLR4-mediated NF-kB signaling (Wang et al. 2011c Hepatology 54: 1421-1432) ; stimulation of bicarbonate secretion from cholangiocytes (Li et al. 2011e Mol. Endocrinol. 25: 1066-1071) ; stimulation of GLP1 secretion from enteroendocrine [L cells](brain://L1WHVYiMxUGm0No…

References (Sources)

Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
McMahan et al. 2013 J. Biol. Chem. 288: 11761-11770
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
Katsuma et al. 2005 Biochem. Biophys. Res. Commun. 329: 386-390
Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G protein-coupled bile acid receptors
Brighton et al. 2015 Endocrinology 156: 3961-3970
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450
Review
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
Harach et al. 2012 Sci. Rep. 2: 430
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
Li et al. 2011e Mol. Endocrinol. 25: 1066-1071
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice
Wang et al. 2011c Hepatology 54: 1421-1432

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