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6-Mercaptopurine ribonucleotide (MPRP) is a nucleotide metabolite formed from the antimetabolite drug Mercaptopurine by the enzyme Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
6-Mercaptopurine ribonucleotide (MPRP) is an early and crucial metabolite of Mercaptopurine. It is further metabolized into other active metabolites, such as Thioinosine monophosphate (TIMP) / Thioinosinic acid. This is primarily responsible for the cytotoxic and immunosuppressive effects of the drug.
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