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Systemic glucocorticoids (e.g., prednisone, methylprednisolone) remain the first-line therapy for Acute graft-versus-host disease (acute GVHD), typically initiated at 2 mg/kg/day equivalents. However, retrospective and prospective studies suggest lower doses (1 mg/kg/day) may be equally effective for grades I-II disease without compromising survival or disease control.
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