Clostridioides difficile infection (CDI) (recurrent)

Clostridioides difficile infection (CDI) (recurrent) means >/= 2 recurrences, or those who have had one recurrence and have risk factors for further episodes, including severe and severe complicated CDI (1)

Clostridioides difficile infection (CDI) recurs in 20–35% of patients after treatment of the initial infection, of which up to 60% experience further relapses, typically within 3 weeks after stopping antibiotics (2, 3, 4, 5, 6, 7, 8, 9).

Clostridioides difficile infection (CDI) (recurrent) has a more severe impact on quality of life than Clostridioides difficile infection (CDI) (initial) (10).

References

(1) Mullish et al. 2021
(2) Cornely et al. 2012 Clin Infect Dis 55(Suppl_2): S154-S161
(3) Lessa et al. 2015 N Engl J Med 372: 825–34
(4) Sheitoyan-Pesant et al. 2016 Clin Infect Dis 62(5): 574-580
(5) Dubberke et al. 2018 Clin Infect Dis 67(8): 1198-1204
(6) Gerding et al. 2018 Clin Infect Dis 67(5): 649-656
(7) Feuerstadt et al. 2023 BMC Infect Dis 23: 132
(8) Lowy et al. 2010 N Engl J Med 362: 197-205
(9) Gerding et al. 2015 JAMA 313: 1719-27
(10) Lurienne et al. 2020 J Patient Rep Outcomes 4(1): 14