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Pegylated Liposomal Doxorubicin is a specialized formulation that encapsulates conventional doxorubicin within a bilayer lipidic sphere, which is further surrounded by a polyethylene glycol layer. This innovative design prolongs the drug's presence in the bloodstream and enhances its accumulation within tumors. As a result, this drug maintains a very favorable toxicity profile and can be safely used in combination with other drugs. Unlike doxorubicin, liposomal doxorubicin does not cause cardiac toxicity, but it is associated with predictable muco-cutaneous toxicity.
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