3-Oxol-lithocholic acid (3-oxo LCA)

3-oxolithocholic acid (3-oxoLCA) is a bile acid metabolite that plays a significant role in modulating the immune system, particularly in the gut.

Gut bacteria convert the secondary bile acid lithocholic acid into 3-oxolithocholic acid (3-oxoLCA). 3-oxoLCA has been identified as an inhibitor of T helper 17 (TH17) cell differentiation
Paik et al. 2022 Nature 603: 907

The bile acid metabolite produced by gut bacteria 3-oxolithocholic acid (3-oxoLCA) inhibits Th17 cell differentiation. The administration of 3-Oxol-lithocholic acid (3-oxoLCA) and Isoallol-lithocholic Acid to mice reduced Th17 cell differentiation and increased T reg cell differentiation, respectively, in the intestinal lamina propria
Hang et al. 2019 Nature 576: 143-148

see also:
Bile Acids / Bile Salts & Immunity
Isoallol-lithocholic Acid