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Experimental studies have demonstrated that luminal antigens play a role in chronic intestinal inflammatory disorders, including Crohn's disease and ulcerative colitis. Modifying the intestinal microflora through antibiotic or probiotic therapy can potentially induce and sustain remission (1)
It is a randomized, placebo-controlled trial studying Lacticaseibacillus rhamnosus GG (LGG) or placebo in 11 randomized patients with moderate to active Crohn's disease (CD) (1)
Sustained remission, defined as freedom from relapse at the 6 months follow-up visit. Relapse was defined as an increase in CDAI of >100 points (1)
Out of the 11 patients who participated in the study, 5 completed it. In each group, 2 patients achieved sustained remiss…