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Epidemiologic studies about DG show heterogeneous data: in a study, among type 1 and type 2 diabetic patients with GI symptoms, the incidence of documented gastroparesis was 60% [35], while a more recent community-based study showed a ten-year cumulative incidence of gastroparesis of 5.2% in type 1 diabetes versus 1% in type 2 diabetes [36].
Whilst GE is often delayed in gastroparesis, the entity of motility alteration has a poor correlation with the severity of symptoms [37].
Histological findings in both diabetic and non-diabetic gastroparetic patients showed loss of interstitial cells of Cajal (ICCs) and ganglion cells, fibrosis of the pylorus and lymphocytic infiltration around myenteric plexus [37].
Notably, gastroparesis and FD show the same histopathologi…